Patient-Reported Outcomes

6. Conclusion: Label What We Measure

Table 3

Condition Clinical Signs & Symptoms  Aspects of Life Affected 
Acne An inflammatory skin condition characterized by superficial skin eruptions around hair follicles. Major Symptoms: Skin rash or lesion on the face, neck, chest, shoulders and back / comedones (whiteheads or blackheads) / pustules / cysts / papules / nodules / inflammation around the skin eruptions
  • Going to social events like dances
  • Feeling depressed and lonely
  • Itching, redness, raw skin (symptoms)
  • Difficulty finding romantic partners
Osteoarthritis Degeneration of the cartilage that lines the joints. Major Symptoms: pain/tenderness, swelling, creaking, stiffening of affected joints, weakness & shrinkage of surrounding muscles due to lack of use (because of pain), enlarged & distorted joints
  • Difficulty bending, kneeling, stooping
  • Difficulty walking up hill
  • Depressed
  • Difficulty turning over in bed

In addition to content validity, the other psychometric properties of quality-of-life measures include:

  1. Specification of the measurement model including the instrument’s scale and sub-scale structure and the conceptual and empirical basis for combining multiple items into a single score;
  2. Reliability, including the degree to which the instrument is free from random error either by testing the homogeneity of content on multi-item tests with internal consistency evaluation or testing the degree to which the instrument yields stable scores over time;
  3. Construct, criterion, and predictive validity wherein the logical relationships among different measures are examined;
  4. Responsiveness or ability of the measure to assess change over time when real change has occurred (longitudinal construct validation); and
  5. Interpretation of the effect size, or the degree to which one can assign qualitative meaning to an instrument’s quantitative scores (Scientific Advisory Committee, Medical Outcomes Trust, 2002; Patrick et al., 2007).

Note that rigorous adherence to standards of measurement of PROs is as important as finding the most appropriate label for what is being measured.