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Table 2

Point estimate and 95% confidence interval (CI) for the difference in mean weight change from baseline between the active drug and placebo groups in four hypothetical trials of two weight reduction drugs.

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D Wang & A Bakhai, (Ed.s). (2006) Clinical Trials: A practical guide to design, analysis and reporting. London: Remedica.

Table 2


Point estimate and 95% confidence interval (CI) for the difference in mean weight change from baseline between the active drug and placebo groups in four hypothetical trials of two weight reduction drugs.

Trial Drug No. of patients per group Difference in mean weight change from baseline (kg) between the active drug and placebo groups Standard deviation of difference Standard error of difference 95% CI for difference P-value
1 A 40 -6 15 3.4 -12.6 0.6 0.074
2 A 400 -6 15 1.1 -8.1 -3.9 0.001
3 B 40 -4 15 3.4 -10.6 2.6 0.233
4 B 800 -2 15 0.8 -3.5 -0.5 0.008