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Cluster Unit Randomized Trials

1. Learning Objectives

After reviewing this chapter readers should be able to:

  • Recognize when cluster randomization should be preferred to individual randomization;
  • Understand the statistical implications of cluster randomization;
  • Understand the advantages and disadvantages of different cluster randomization designs;
  • Understand the basic principles of sample size estimation for cluster randomization designs;
  • Be able to select an appropriate method of statistical analysis; and
  • Be able to adequately report the results of a cluster randomization trial.